Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation against an subterranean weapons facility in Syria operated by the Daesh militant organization, as stated by the British defence ministry.
The facility, identified by reconnaissance, was assessed as storing arms and explosives, the announcement noted, and was positioned in mountainous terrain just north of Palmyra in central Syria.
"Our aircraft utilized precision-guided Paveway IV munitions to strike a several entry passages providing entry to the site... initial indications are that the objective was successfully hit," the MoD said.
There was no evidence of any civilian casualties in the strike late on Saturday and all the aircraft returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - referred to as the so-called Islamic State - established militant control over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates the UK's leading role, and determination to work closely with our partners, to eliminate any re-emergence of Daesh and their harmful and extremist ideologies in the region," the British Defence Secretary the minister stated.
British military aircraft have performed surveillance missions over Syria to "prevent any efforts to regroup" of the group following its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I want to thank every member of the UK armed forces involved in this strike for their skill and their bravery," Healey said. "They were part of a great many British personnel on duty over the holidays. This action, to take out militants who pose a risk to our safety, highlights how our armed forces are ready to step up, throughout the year, protecting the UK domestically and strong abroad."
During December, the American forces executed what it called a "major assault" targeting Daesh sites in the country, following an ambush killed two American soldiers and a civilian interpreter in the Palmyra area.
The U.N. says Islamic State still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.